Related Experiment Videos
[Collagenous colitis: presentation of 12 cases]
P Rivera1, S Pamos, J Cuquerella
1Servicio de Patología Digestiva, Hospital General Universitario de Valencia.
Gastroenterologia Y Hepatologia
|March 21, 1998
Summary
Collagenous colitis (CC) causes chronic diarrhea despite normal endoscopic views. Diagnosis requires a colon biopsy showing a thickened collagen band and inflammation.
Area of Science:
- Gastroenterology
- Pathology
- Immunology
Context:
- Collagenous colitis (CC) presents as chronic aqueous diarrhea with unremarkable endoscopic findings.
- Histological examination reveals a thickened subepithelial collagen band and mucosal inflammation, defining CC.
- The etiology of CC remains unclear, with proposed mechanisms including autoimmune, inflammatory, collagen synthesis dysregulation, vasculosis, or toxin involvement.
Purpose:
- To present clinicopathological data of 12 patients diagnosed with collagenous colitis.
- To evaluate treatment responses in patients with collagenous colitis.
- To provide a literature review on collagenous colitis.
Summary:
- Twelve patients (9 female, 3 male; mean age 52.4 years) with CC experienced chronic diarrhea (mean 5.4 stools/day).
- Six patients had allergies or associated rheumatologic diseases; laboratory and endoscopic data were non-specific.
- Colon biopsies confirmed CC. Treatments like sulphasalazine, corticoids, antibiotics, and mebeverine showed variable efficacy, with two patients remaining unresolved.
Impact:
- Highlights the diagnostic importance of colon biopsies in unexplained chronic diarrhea.
- Suggests potential therapeutic targets and the need for further etiological research in CC.
- Contributes clinicopathological data to the understanding of collagenous colitis and its management.