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A study on ester thiosemicarbazones
A A Ikizler1, B Kahveci, C B Johansson
1Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
Acta Poloniae Pharmaceutica
|July 1, 1997
Abstract:
The cyclization of ester thiosemicarbazones to two different heterocycles was studied for some new thiosemicarbazones, and only the formation of 1,2,4-triazol-5-thiols was attributed to the regioselectivity of the ring closure reaction, due to a steric hindrance of bulky groups. Next, some of the new compounds were tested for their in vitro antimicrobial and antitumor activities.