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Pediatric scleroderma

H Emery1

  • 1Department of Pediatrics, University of California at San Francisco, 94143-0105, USA.

Seminars in Cutaneous Medicine and Surgery
|March 25, 1998
PubMed
Summary
This summary is machine-generated.

Scleroderma in children involves skin and tissue fibrosis, often localized, causing asymmetry and disability. Pediatric management requires careful consideration of medication side effects and psychosocial impacts.

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Area of Science:

  • Pediatric Rheumatology
  • Dermatology
  • Systemic Autoimmune Diseases

Background:

  • Scleroderma encompasses diverse conditions characterized by fibrosis of skin and other tissues.
  • While less common in children, scleroderma significantly impacts pediatric morbidity and mortality.
  • Localized forms are more prevalent in children, potentially leading to growth issues, asymmetry, and functional disability.

Purpose of the Study:

  • To describe types of scleroderma in children.
  • To review epidemiologic and etiologic factors of pediatric scleroderma.
  • To discuss management strategies for childhood scleroderma.

Main Methods:

  • Literature review of scleroderma in pediatric populations.
  • Analysis of existing case series and clinical observations.

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  • Synthesis of current understanding of disease presentation and progression.

    • Main Results:

    • Children predominantly develop localized scleroderma, unlike adults.
    • Potential complications include facial/limb asymmetry, contractures, and functional impairment.
    • Management must balance treatment efficacy with adverse effects like growth failure and osteoporosis.

    Conclusions:

    • Childhood scleroderma presents unique challenges, particularly localized forms impacting growth and development.
    • Multidisciplinary management is crucial, addressing both physical and psychosocial aspects.
    • Further controlled studies are needed due to the rarity of large patient cohorts.