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Related Experiment Videos

Do transmembrane protein superfolds exist?

D T Jones1

  • 1Department of Biological Sciences, University of Warwick, Coventry, UK. jones@globin.bio.warwick.ac.uk

FEBS Letters
|March 27, 1998
PubMed
Summary
This summary is machine-generated.

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Transmembrane proteins, unlike globular proteins, show favored fold families. Analysis of predicted membrane spanning segments and topology reveals significant biases, indicating common transmembrane protein structures.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Globular proteins exhibit favored fold families.
  • The existence of favored fold families for transmembrane proteins remains debated.
  • Transmembrane proteins play crucial roles in cellular functions.

Purpose of the Study:

  • To investigate whether transmembrane proteins have favored fold families.
  • To re-examine the hypothesis of no favored transmembrane protein fold families.
  • To identify biases in transmembrane protein topologies.

Main Methods:

  • Application of a reliable transmembrane protein structure prediction algorithm.
  • Analysis of five representative genomic sequence data sets.
  • Evaluation of predicted membrane spanning segments and their topology.

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Main Results:

  • Observed definite biases in transmembrane protein topologies.
  • Identified specific transmembrane topologies as significantly more common.
  • Challenged the hypothesis of no favored transmembrane protein fold families.

Conclusions:

  • Transmembrane proteins exhibit favored fold families, contrary to previous hypotheses.
  • The number and topology of membrane spanning segments influence protein structure.
  • Specific transmembrane topologies are significantly prevalent.