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[The characteristics of protein p66--a substrate of the epidermal growth factor receptor]
D B Tvorogov1, A D Blagoveshchenskaia, N V Tsupkina
1Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Tsitologiia
|January 1, 1997
Abstract:
The p66-kDa protein--a substrate of EGF receptor, is characterized. It is shown that the molecule of p66 is recognized by antibodies to phospholipase C gamma 1, includes conservative SH2--SH3 domains and lacks N-terminal part of PLC gamma 1. Protein p66 is associated to the EGF-R molecule on 992 tyrosine. Protein p66 binds to both membrane and internalized EGF-Rs and is redistributed with the receptors during receptor-mediated endocytosis. It is supposed that p66 may play a regulatory role in signal transduction.