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Interaction of sulfhydryl reagents with K+ transport in adrenal chromaffin granules
A Szewczyk1, N A Lobanov, M Nowotny
1Department of Molecular and Cell Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland. adam@nencki.gov.pl.
Acta Neurobiologiae Experimentalis
|January 1, 1997
Abstract:
In the present study the functional role of SH groups in the Ca(2+)-independent K(+)-selective channel activity in the membrane of bovine adrenal gland chromaffin granules has been studied. Ionic channel activity has been estimated using 86Rb+, a K+ analogue, flux measurements. The inhibition of chromaffin granules K+ channel by SH modifying agents, such as N-ethylmaleimide, mersalyl and phenylarsenoxide, is described.