Related Experiment Video
Updated: Sep 2, 2026

Induction and Monitoring of Active Delayed Type Hypersensitivity (DTH) in Rats
Published on: July 18, 2007
[Delayed-type hypersensitivity induced by digestive immunization and suppression of this induction by
Abstract:
BALB/c mice were immunized by intragastric administration of sheep red blood cells or horse red blood cells repeated daily for 4 days. The immunized animals when skin tested with an urea extract of the corresponding antigen showed a delayed-type hypersensitivity reaction. This reaction was observed for 4 weeks after the immunization. This result demonstrates that digestive immunization may induce cellular immunity. When serum from intragastrically immunised mice containing antigen-antibody complexes was administered intraperitoneally 8 hours before the onset of digestive immunization, the subsequent delayed-type hypersensitivity reaction was suppressed or considerably depressed.
Related Concept Videos
Allergic Drug Reactions
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Hypersensitivity Reactions: Cytolytic Reactions
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Hypersensitivity Reactions: Immune-Complex Reactions

