Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CREB and memory

A J Silva1, J H Kogan, P W Frankland

  • 1Cold Spring Harbor Laboratory, Harbor, New York 11724, USA. silva@cshl.org

Annual Review of Neuroscience
|April 8, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing radish (Raphanus sativus L.) production through alternative nitrogen sources.

Brazilian journal of biology = Revista brasleira de biologia·2026
Same author

Microbiolization of Arachis hypogaea L. seeds.

Brazilian journal of biology = Revista brasleira de biologia·2026
Same author

Potassium silicate on the productivity of Opuntia stricta Haw and the infestation by Diaspis echinocacti.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

The state of the art in Blue Amazon biodiversity: Protocol for a systematic review.

MethodsX·2025
Same author

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity.

bioRxiv : the preprint server for biology·2024
Same author

Filter cake increases sugarcane yield.

Brazilian journal of biology = Revista brasleira de biologia·2023
Same journal

Body-Brain Integration: The Lower Brainstem in Sleep-Wake Regulation.

Annual review of neuroscience·2026
Same journal

Planning in the Brain: It's Not What You Think It Is.

Annual review of neuroscience·2026
Same journal

The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.

Annual review of neuroscience·2026
Same journal

Rethinking Predictive Processing.

Annual review of neuroscience·2026
Same journal

Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.

Annual review of neuroscience·2026
Same journal

The Cellular and Circuit Basis of Temperature Sensation in <i>Drosophila</i>.

Annual review of neuroscience·2026
See all related articles

The cAMP responsive element binding protein (CREB) is crucial for long-term memory formation. Studies across species show CREB-dependent transcription is essential for consolidating memories, highlighting its universal role in learning.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • CREB is a nuclear protein regulating gene transcription via cAMP responsive elements.
  • CREB activation is triggered by calcium or cAMP signaling pathways.
  • CREB influences diverse biological functions including memory, circadian rhythms, and spermatogenesis.

Purpose of the Study:

  • To review the characteristics of CREB-dependent transcription.
  • To examine the role of CREB in memory formation across different species.

Main Methods:

  • Review of existing literature on CREB function.
  • Analysis of genetic and pharmacological studies in model organisms (Aplysia, Drosophila, mice, rats).

Main Results:

Related Experiment Videos

  • CREB-dependent transcription is essential for long-term memory consolidation.
  • CREB is implicated in various complex memory forms, including spatial and social learning.
  • Evidence suggests CREB is a universal modulator of memory formation processes.

Conclusions:

  • CREB-dependent transcription is a fundamental mechanism for long-term memory.
  • CREB plays a conserved and critical role in diverse forms of learning and memory.