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Butenafine

W McNeely1, C M Spencer

  • 1Adis International Limited, Auckland, New Zealand. demail@adis.co.nz

Drugs
|April 8, 1998
PubMed
Summary
This summary is machine-generated.

Butenafine demonstrates potent antifungal activity against dermatophytes causing tinea infections. Clinical studies show high mycological and overall cure rates for tinea pedis, cruris, and corporis, with sustained efficacy after treatment cessation.

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Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Butenafine is a novel antifungal agent.
  • It exhibits primary fungicidal activity against common dermatophytes responsible for tinea infections.

Purpose of the Study:

  • To evaluate the efficacy and pharmacokinetic profile of butenafine.
  • To compare butenafine's in vitro activity with other antifungal agents.

Main Methods:

  • In vitro susceptibility testing of butenafine against dermatophytes.
  • Pharmacokinetic study using 14C-labelled butenafine in guinea-pig skin.
  • Clinical trials in patients with tinea pedis, tinea cruris, and tinea corporis.

Main Results:

  • Butenafine showed potent in vitro fungicidal activity, with Minimum Fungicidal Concentrations (MFC) significantly lower than naftifine, tolnaftate, clotrimazole, and bifonazole.

Related Experiment Videos

  • Topical butenafine distributed into the epidermis and dermis of guinea-pig skin.
  • Clinical trials demonstrated high mycological and overall cure rates in patients treated with butenafine for various tinea infections, with sustained efficacy post-treatment.

    • Conclusions:

    • Butenafine possesses strong fungicidal properties and favorable pharmacokinetic distribution.
    • It offers a promising therapeutic option for dermatophytoses, showing high and sustained cure rates in clinical settings.