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Updated: Aug 5, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Mono and double modified teicoplanin aglycon derivatives on the amino acid no. 7; structure-activity relationship
A Y Pavlov1, M N Preobrazhenskaya, A Malabarba
1Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow, Russia.
Abstract:
A series of 7d-aminomethylated derivatives (mono modified) and their amides (double modified) at the amino acid No. 7 of teicoplanin aglycon were prepared with the aim of obtaining activity against vancomycin-resistant VanA enterococci. Among mono modified compounds, the 7d-n-decylaminomethyl derivative was the most active against VanA enterococci (4 micrograms/ml). Amides of the latter with 3-dimethylamino-propylamine or methylamine were found to be up to four times more active against glycopeptide-susceptible Gram-positive bacteria, and up to four times less active against VanA enterococci than the starting compound.
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