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Beta-adrenergic blockade does not prevent polycythemia or decrease in plasma volume in men at 4300 m altitude

R F Grover1, M A Selland, R G McCullough

  • 1Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262, USA.

European Journal of Applied Physiology and Occupational Physiology
|April 16, 1998
PubMed
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Beta-blocker use did not alter fluid volume or red blood cell production during high-altitude exposure. This suggests the beta-adrenergic system does not significantly impact hypovolemic or polycythemic responses at altitude.

Area of Science:

  • Physiology
  • Altitude Medicine
  • Cardiovascular Physiology

Background:

  • High altitude (ALT) exposure initially decreases plasma volume (PV) and total blood volume (BV).
  • Hypoxia stimulates erythropoietin (EPO) and the beta-adrenergic system, potentially influencing red blood cell production and BV restoration.
  • The role of the beta-adrenergic system in mediating these altitude-induced fluid and hematological changes requires further investigation.

Purpose of the Study:

  • To investigate the effect of beta-adrenergic receptor inhibition using propranolol on fluid volumes and polycythemic responses during prolonged high-altitude exposure.
  • To determine if the beta-adrenergic system modulates the hypovolemic and polycythemic adaptations to altitude.

Main Methods:

  • 11 healthy men resided at 4300 m for 3 weeks, receiving either propranolol or a placebo.
Keywords:
NASA Center ARCNASA Discipline Regulatory Physiology

Related Experiment Videos

  • Measurements included plasma volume (PVEB), total blood volume (BVCO), red cell volume (RCVCO), serum erythropoietin concentration ([EPO]), and reticulocyte count.
  • All measurements were taken at sea level and after 10 and 20 days at altitude.

    • Main Results:

    • Propranolol did not significantly alter maximal [EPO] or reticulocyte count.
    • Beta-blockade did not affect changes in plasma volume, red cell volume, or total blood volume compared to placebo.
    • No significant differences in hypovolemic or polycythemic responses were observed between the propranolol and placebo groups.

    Conclusions:

    • Activation of the beta-adrenergic system does not appear to significantly influence the hypovolemic or polycythemic responses during 3 weeks of high-altitude exposure.
    • Fluid volume and red blood cell production adaptations at altitude are likely mediated by pathways independent of beta-adrenergic signaling.
    • These findings suggest that beta-blockade does not alter key physiological adjustments to high altitude in healthy individuals.