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A simple method for "reference range" estimation from routine laboratory data

S Y Chu, P Cheung, V E Turkington

    Clinical Biochemistry
    |August 1, 1976
    PubMed
    Summary
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    A new simplified method estimates laboratory reference ranges using hospital data, even with abnormal values. This approach provides reliable results comparable to those for healthy individuals.

    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Biostatistics

    Background:

    • Establishing accurate reference ranges is crucial for diagnosing and monitoring diseases.
    • Traditional methods often require extensive data from strictly healthy populations, which can be difficult to obtain.
    • Hospital laboratory data frequently includes values from both healthy and diseased individuals, complicating range determination.

    Purpose of the Study:

    • To present a simplified and robust method for estimating clinical laboratory reference ranges.
    • To demonstrate the applicability of this method using routine hospital laboratory data, including abnormal values.
    • To validate the derived reference ranges against established values for healthy subjects.

    Main Methods:

    • A graphical estimation technique was employed to assess the relative proportions of normal and abnormal populations within the data.

    Related Experiment Videos

  • The 'mode-center' concept was utilized, positioning the total population's mode at the 50% cumulative frequency of the normal population.
  • The method was applied to determine reference ranges for Blood Urea Nitrogen (BUN) and calcium levels.

    • Main Results:

    • The simplified method successfully estimated reference ranges from hospital laboratory data containing both normal and abnormal values.
    • Reference ranges derived for BUN and calcium were comparable to those previously reported for healthy populations.
    • The method proved effective even when the data source included significantly high and/or low values.

    Conclusions:

    • The presented simplified method offers a practical approach to establishing reliable reference ranges from readily available hospital laboratory data.
    • This technique overcomes limitations of traditional methods by accommodating data with abnormal values.
    • The findings suggest this method is a viable tool for routine laboratory use, enhancing diagnostic accuracy.