Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental models for studying mucociliary clearance

M King1

  • 1Pulmonary Research Group, University of Alberta, Edmonton, Canada.

The European Respiratory Journal
|May 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sexual dysfunction after treatment for testicular cancer: a systematic review.

Journal of psychosomatic research·2001
Same author

Straight talking: an investigation of the attitudes and practice of psychoanalysts and psychotherapists in relation to gays and lesbians.

The British journal of psychiatry : the journal of mental science·2001
Same author

Medicaid's home- and community-based waiver.

NCSL legisbrief·2001
Same author

Practical method for evaluation of linearity and effective pathlength of on-capillary photometric detectors in capillary electrophoresis.

Journal of chromatography. A·2001
Same author

The royal free interview for spiritual and religious beliefs: development and validation of a self-report version.

Psychological medicine·2001
Same author

A comparison of three measures: the time trade-off technique, global health-related quality of life and the SF-36 in dialysis patients.

Journal of clinical epidemiology·2001
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
Same journal

ERS Statement on ultrasound guided interventions in respiratory disease.

The European respiratory journal·2026
Same journal

When symptoms and resting tests disagree in interstitial lung disease: a selective role for cardiopulmonary exercise testing.

The European respiratory journal·2026
Same journal

Clinical Practice Guideline for the diagnosis of Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD) in patients with Common Variable Immunodeficiency Disorders (CVID) - an ERS Clinical Research Collaboration.

The European respiratory journal·2026
Same journal

SARS-CoV-2 (E)-protein induces rapid TLR2-mediated T cell activation in mouse lungs revealed by intravital lung microscopy.

The European respiratory journal·2026
Same journal

Functional characterization of <b><i>KCNA5</i></b> gene variants linked to pulmonary arterial hypertension.

The European respiratory journal·2026
See all related articles

Understanding respiratory mucus rheology is key to mucociliary clearance. Animal models, from ex vivo tissues to large mammals, aid in studying mucus secretion and clearance mechanisms.

Area of Science:

  • Biomedical Engineering
  • Respiratory Physiology

Background:

  • Respiratory tract mucus is a viscoelastic gel.
  • Mucus rheology and quantity, along with ciliary function, are critical for mucociliary clearance.

Purpose of the Study:

  • To review available animal models for studying mucus secretion and clearance.
  • To highlight the advantages and limitations of different models for rheological characterization and clearance assessment.

Main Methods:

  • Ex vivo models (frog palate, bovine trachea) for direct mucus clearability data.
  • Rodent models (chronic bronchitis via irritant gas/smoke) for studying disease features.
  • Large animal models (dog, sheep) for integrated, long-term measurements.

Main Results:

Related Experiment Videos

  • Ex vivo models offer direct clearability insights.
  • Rodent models mimic chronic bronchitis features efficiently.
  • Large animal models allow comprehensive, serial measurements of mucus properties and clearance.

Conclusions:

  • A range of animal models exist for studying respiratory mucus and mucociliary clearance.
  • Model selection depends on the specific research question, balancing cost, data quality, and measurement integration.