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Neurodevelopmental and neuroprogressive processes in schizophrenia. Antithetical or complementary, over a lifetime
J L Waddington1, A Lane, P J Scully
1Department of Clinical Pharmacology, Royal College of Surgeons in Ireland.
The Psychiatric Clinics of North America
|April 29, 1998
Abstract:
The neurodevelopmental model of schizophrenia maintains ascendancy among current etiopathologic perspectives on schizophrenia. However, inconsistencies across studies and the absence thus far of pathognomic brain changes suggest the need for complex conceptualization of neurodevelopmental arrest, including some reconciliation with the competing neurodegenerative model of schizophrenia. This article critically reviews the preponderance of evidence for each model and provides an account of how these may interact or synergize to produce the characteristic clinical expression of schizophrenia.