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Structural basis for chemical inhibition of CDK2
S H Kim1, U Schulze-Gahmen, J Brandsen
1Department of Chemistry, Lawrence Berkeley National Laboratory, University of California 94720, USA.
Progress in Cell Cycle Research
|January 1, 1996
Abstract:
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for discovering small inhibitory molecules that can modify the degree of cell proliferation. The three-dimensional structure of CDK2 provides a structural foundation for understanding the mechanisms of activation and inhibition of CDK2 and for the discovery of inhibitors. In this article five structures of human CDK2 are summarised: apoprotein, ATP complex, olomoucine complex, isopentenyladenine complex, and des-chloro-flavopiridol complex.