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[Hearing loss caused by high dose carboplatin therapy]
J Lautermann1, M Adamczyk, W J ten Cate
1Universitäts-Hals-Nasen-Ohrenklinik Essen.
Background:
Carboplatin is regarded as a non-ototoxic or low-grade ototoxic chemotherapeutic agent.
Method:
We report on three patients with a recurrence of testicular cancer after cisplatin chemotherapy who suffered hearing loss after subsequent high-dose carboplatin therapy.
Results:
Audiometry demonstrated carboplatin-induced hearing loss primarily in the mid-range and high frequencies up to 45 dB at 3 kHz and up to 55 dB at 8 kHz. In two of three patients, transitory-evoked otoacoustic emissions were absent after carboplatin therapy.
Conclusion:
Following first-line cisplatin chemotherapy, salvage treatment with high-dose carboplatin can generate hearing loss in the middle and high frequencies.
