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Related Experiment Videos

Rewiring a receptor: negative output from positive input

B L Taylor1, M S Johnson

  • 1Department of Microbiology and Molecular Genetics, and Center for Molecular Biology and Gene Therapy, School of Medicine, Loma Linda University, CA 92350, USA. blTaylor@ccmail.llu.edu

FEBS Letters
|May 1, 1998
PubMed
Summary
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Bacterial chemotaxis receptors can be rewired to reverse their responses to attractants and repellents. A new model explains this by a critical residue

Area of Science:

  • Molecular Biology
  • Microbiology
  • Biophysics

Background:

  • Bacterial chemotaxis receptors mediate responses to environmental stimuli.
  • Specific modifications can invert receptor signaling, causing attraction to repellents and vice versa.
  • The underlying mechanisms for these inverse responses are not fully understood.

Purpose of the Study:

  • To investigate the mechanism by which bacterial chemotaxis receptors produce inverse signals.
  • To propose a generalized model for receptor signal transduction.
  • To explain how point mutations or covalent modifications alter chemotaxis responses.

Main Methods:

  • Theoretical modeling of receptor signal transduction.
  • Analysis of existing data on bacterial chemotaxis responses.

Related Experiment Videos

  • Generalization of the model to other signaling systems.

    • Main Results:

    • A model is presented where the orientation of a critical residue dictates normal or inverted signaling.
    • This model explains observed inverse responses in bacterial chemotaxis.
    • The proposed mechanism is consistent with diverse conditions causing altered receptor behavior.

    Conclusions:

    • Receptor signal transduction is readily re-wireable, leading to inverse responses.
    • A simple structural change, residue orientation, can fundamentally alter signaling output.
    • The model provides a framework applicable to various signal transduction systems beyond bacterial chemotaxis.