Synthesis and cytotoxicity of the three-membered aromatic pyrimidine derivatives

A series of the three-membered aromatic anthracene, acridine, carbazole substituted with pyrimidine moiety equipped with pharmacophoric chain of N'-(2'-hydroxyethyl)ethylenediamine or dialkylamino-3-propylamine was obtained and tested for the cytotoxic properties in SRB test. The synthesis was performed from 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-thio-5-pyrimidinecarboxylic acid or its ethyl ester and three-membered aromatic amines (e.g. 9-aminoacridine). Some of the compounds showed significant cytotoxic activity.