Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Occasions for multiple flaps in lower-limb reconstructions: once is sometimes not enough

J S Isenberg1

  • 1Midwest City Regional Medical Center, Oklahoma, USA.

Journal of Reconstructive Microsurgery
|May 20, 1998
PubMed
Summary

Microvascular transfers are highly effective for complex lower-limb defects, achieving wound closure in most cases. Local flaps alone were insufficient, highlighting transfers as a crucial solution when other options fail.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
Same author

Thrombospondin-1: a physiological regulator of nitric oxide signaling.

Cellular and molecular life sciences : CMLS·2008
Same author

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

British journal of pharmacology·2007
Same author

Type I collagen is a molecular target for inhibition of angiogenesis by endogenous thrombospondin-1.

Oncogene·2005
Same author

Nitric oxide modulation of low-density mononuclear cell transendothelial migration.

Microsurgery·2005
Same author

Incentivized digital outcomes collection.

American journal of medical quality : the official journal of the American College of Medical Quality·2002

Area of Science:

  • Orthopedic Surgery
  • Plastic Surgery
  • Reconstructive Surgery

Background:

  • Complex and massive lower-limb defects pose significant reconstructive challenges.
  • Traditional methods may be insufficient for extensive tissue loss.
  • Evaluating the efficacy of microvascular transfers versus local flaps is critical.

Observation:

  • A retrospective review analyzed 11 patients with severe lower-limb defects.
  • Treatment involved multiple microvascular transfers and/or regional muscle flaps.
  • Outcomes were assessed based on final wound closure and reconstructive success.

Findings:

  • Microvascular transfers, alone or with local flaps, achieved successful wound closure in 10 out of 11 patients.
  • Local flaps alone were inadequate for reconstruction in cases where transfers failed.

Related Experiment Videos

  • This indicates the superior utility of microvascular free tissue transfers.

    • Implications:

    • Microvascular transfers represent a primary and often essential reconstructive strategy for massive lower-extremity defects.
    • These techniques offer a viable solution when other reconstructive options have been exhausted.
    • The findings support the consideration of microvascular free tissue transfers as an initial approach in complex cases.