Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry

J C Wijkmans1, A J Culshaw, A D Baxter

  • 1Oxford Diversity, A Division of Oxford Asymmetry Ltd., Abingdon, Oxon, UK.

Molecular Diversity
|January 1, 1997
PubMed
Summary

This study introduces a new method for creating biaryl ethers and thioethers using a solid support. This approach allows for efficient synthesis and potential for generating diverse chemical libraries.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterotopic pregnancy in non-communicating horn of bicornuate uterus: a novel management approach.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2011
Same author

Hospital almoning.

Surgo; Glasgow University medical journal·2010
Same author

Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors.

Bioorganic & medicinal chemistry letters·2001
Same author

Solid-phase synthesis and biological screening of N-alpha-mercaptoamide template-based matrix metalloprotease inhibitors.

Combinatorial chemistry & high throughput screening·2000
Same author

The synthesis and antiviral activity of 4-fluoro-1-beta-D-ribofuranosyl-1H-pyrazole-3-carboxamide.

Nucleosides & nucleotides·1999
Same author

Novel modified tripeptide inhibitors of alpha 4 beta 7 mediated lymphoid cell adhesion to MAdCAM-1.

Bioorganic & medicinal chemistry letters·1999

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Synthetic Chemistry

Background:

  • Biaryl ethers and thioethers are important structural motifs in pharmaceuticals and materials.
  • Efficient and versatile synthetic methods are crucial for accessing these compounds.
  • Solid-phase synthesis offers advantages in purification and library generation.

Purpose of the Study:

  • To develop a mild and efficient method for synthesizing biaryl ethers and thioethers.
  • To demonstrate the utility of the developed method for combinatorial library generation.

Main Methods:

  • Immobilization of 4-fluoro-3-nitrobenzoic acid onto a solid support.
  • Reaction of the immobilized substrate with various functionalized phenols and thiophenols under mild conditions.

Related Experiment Videos

  • Cleavage of the product from the solid support.
  • Further elaboration of immobilized biaryl ethers.

    • Main Results:

    • High yields and excellent purity of the resulting biaryl ethers and thioethers were achieved.
    • The method demonstrated compatibility with a wide range of functionalized phenols and thiophenols.
    • The immobilized biaryl ethers could be further modified, indicating potential for library synthesis.

    Conclusions:

    • The developed solid-phase synthesis is an effective strategy for preparing biaryl ethers and thioethers.
    • This method provides a valuable tool for the rapid generation of diverse chemical libraries for drug discovery and materials science.