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Related Experiment Videos

Leukocytoclastic vasculitis associated with clarithromycin

S R Gavura1, S Nusinowitz

  • 1Department of Pharmacy Services, Mount Sinai Hospital, Toronto, Ontario, Canada. scott.gavura@utoronto.ca

The Annals of Pharmacotherapy
|June 2, 1998
PubMed
Summary
This summary is machine-generated.

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A rare case of leukocytoclastic vasculitis (LCV) occurred in an elderly woman treated with clarithromycin. Symptoms resolved after discontinuing the antibiotic, highlighting LCV as a serious potential adverse effect of clarithromycin.

Area of Science:

  • Pharmacology
  • Dermatology
  • Pathology

Background:

  • Antibiotic-induced hypersensitivity reactions can manifest in various forms.
  • Leukocytoclastic vasculitis (LCV) is a recognized category of drug hypersensitivity.

Observation:

  • An 83-year-old woman developed purpuric, nonblanching lesions on her extremities and abdomen six days after initiating clarithromycin for pneumonia.
  • Gastrointestinal mucosa showed erythema and edema; skin biopsy confirmed LCV.
  • Symptoms resolved upon clarithromycin withdrawal and corticosteroid treatment.

Findings:

  • The presented case aligns with previously reported instances of clarithromycin-associated LCV.
  • This adverse drug reaction is characterized by perivascular inflammation.

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Implications:

  • Physicians should consider LCV in patients presenting with vasculitic symptoms during clarithromycin therapy.
  • Early recognition and drug withdrawal are crucial for managing this rare but serious adverse effect.