Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probenecid hypersensitivity in AIDS: a case report

K W Myers1, R K Katial, R J Engler

  • 1Department of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC 20307, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|June 3, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Occurrence of methicillin-resistant Staphylococcus aureus in surface waters near industrial hog operation spray fields.

The Science of the total environment·2016
Same author

Induction and measurement of in vivo antibody responses.

Current protocols in immunology·2008
Same author

Mosquito bite pathogenesis in necrotic skin reactors.

Current opinion in allergy and clinical immunology·2002
Same author

Characterization of aerosol output from various nebulizer/compressor combinations.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001
Same author

Cell-mediated immune response to tuberculosis antigens: comparison of skin testing and measurement of in vitro gamma interferon production in whole-blood culture.

Clinical and diagnostic laboratory immunology·2001
Same author

Alternative and complementary medicine: a source of improved therapies for asthma? A challenge for redefining the specialty?

The Journal of allergy and clinical immunology·2000
Same journal

Overlapping Mechanisms and Novel Biomarkers Define Asthma and COPD as a Spectrum of Airway Disease.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Real-World Variation in Post-Dose Supervision and Activity Restriction During Maintenance Cow's Milk Oral Immunotherapy.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Small Airway Dysfunction and Prior Exacerbations are Common in Primarily Well-Controlled Pediatric Asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Elevated Absolute Eosinophil Counts are Associated with Hypertension, Coronary Heart Disease, and Stroke.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Pharmacokinetics and pharmacodynamics of AQST-109 sublingual film in oral allergy syndrome: A phase 2 study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Biomarkers for COPD with Type 2 Inflammation.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
See all related articles

Cidofovir and probenecid treat herpes and cytomegalovirus in AIDS patients. A new pretreatment regimen helps manage hypersensitivity reactions to probenecid, allowing continued antiviral therapy.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Immunology

Background:

  • Cidofovir combined with probenecid offers a treatment option for cytomegalovirus and acyclovir-resistant herpes infections in patients with acquired immunodeficiency syndrome (AIDS).
  • Probenecid is administered with cidofovir to mitigate the risk of nephrotoxicity associated with cidofovir therapy.

Observation:

  • A patient diagnosed with AIDS experienced a cutaneous hypersensitivity reaction exclusively to probenecid while undergoing treatment for a peri-anal acyclovir-resistant herpetic infection.
  • The patient was receiving a combination therapy of cidofovir and probenecid for the herpetic infection.

Findings:

  • A successful pre-treatment protocol involving prednisone and H1/H2 blockers was implemented to manage the probenecid hypersensitivity reaction.

Related Experiment Videos

  • This regimen enabled the patient to continue with the essential antiviral therapy.

    • Implications:

    • As the use of cidofovir increases in AIDS patients, a rise in hypersensitivity reactions to probenecid is anticipated.
    • The described pre-treatment protocol presents a viable therapeutic strategy for managing probenecid hypersensitivity, ensuring the continuation of vital antiviral treatment.