[Nature of centrogenic reactions developing during surgical interventions on the brain]

The nature of hemodynamic reactions and EEG changes developing during surgery is discussed, based on analysis of 392 interventions for removal of brain tumors. Two main types of centrogenic reactions are distinguished: (1) connected with the direct effect on brain centers engaged in cardiovascular regulation and (2) caused by stimulation of the median structures of the brain, most often caused by hyperperfusion in different compartments of the brain. Use of anesthesiological method limiting the functional relations between the brain stem and forebrain notably decreases the incidence of centrogenic reactions during neurosurgical interventions.