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Conjunction dysfunction: CBP/p300 in human disease

R H Giles1, D J Peters, M H Breuning

  • 1Department of Human Genetics, Leiden University Medical Center, The Netherlands.

Trends in Genetics : TIG
|June 5, 1998
PubMed

Insights

Creb-binding protein (CBP) and its homolog p300 are crucial nuclear proteins involved in gene transcription and cell development. Their dysregulation is linked to various cancers and developmental disorders, highlighting their tumor suppressor roles.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Biology

Background:

  • CBP (Creb-binding protein) and p300 are large nuclear proteins.
  • They regulate transcriptional pathways and chromatin remodeling.
  • These proteins interact with transcription factors and are involved in apoptosis and differentiation.

Purpose of the Study:

  • To investigate the role of CBP and p300 in cell growth regulation.
  • To explore the implications of CBP/p300 competition in cellular processes.
  • To understand the involvement of CBP and p300 in human diseases.

Main Methods:

  • Biochemical analysis of CBP and p300 interactions.
  • Genetic analysis of CBP and p300 alterations in disease.
  • Literature review of existing evidence on CBP/p300 function.

Main Results:

  • Evidence suggests CBP/p300 demand can exceed supply, impacting cell growth.
  • Alterations in the human CBP gene are linked to hematological malignancies and developmental issues.
  • The p300 gene is implicated in leukemia, with mutations found in gastric and colorectal carcinomas.

Conclusions:

  • CBP and p300 play critical roles in cell-cycle control, differentiation, and human development.
  • These proteins function as tumor suppressors.
  • Understanding CBP/p300 is essential for comprehending various human diseases.

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