Olanzapine

Olanzapine is a newly introduced atypical neuroleptic, with a broad receptor profile similar to that of clozapine. It is as effective as haloperidol against the positive symptoms of schizophrenia, and more effective against negative symptoms, with significantly fewer extrapyramidal side-effects. Side-effects include somnolence and weight gain. It may show efficacy in treatment-resistant schizophrenia.