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Plasma pharmacokinetics of a generic amoxycillin and the innovator brand: a comparison
A K Goonetilleke1, J M Munasingha, D S Guruge
1Department of Pharmacology, Faculty of Medical Sciences, University of Sri Jayewardenepura.
Objective:
To compare the bioavailability and plasma pharmacokinetics of a generic brand of amoxycillin (State Pharmaceutical Manufacturing Coporation) selected from the lower price range, with that of the innovation brand (Amoxil, Beecham).
Design:
Sixteen healthy adult volunteers were allotted to two groups and each group was given a test dose of amoxycillin from each brand. Blood samples were collected at 0, 2, 3 and 4 hours thereafter plasma levels were assayed using high performance liquid chromatography.
Results:
Analysis of results show that the generic product had similar bioavailability and pharmacokinetics when compared with the innovator product.
Conclusion:
The quality assured generic amoxycillin tested had similar bioavailability as a more costly branded version.