Variations in blood flow waveforms in stenotic renal arteries by 2D phase-contrast cine MRI

Waveform variations in blood flow measurements through stenotic renal arteries have been reported already with echo Doppler studies. We studied these variations with MRI in 14 patients (mean age, 60 years) with suspected renal arterial stenosis (24 patent arteries, four occluded). Flow measurements were successful in 15 arteries and unsuccessful in nine, due to practical limitations. Seven healthy younger volunteers (mean age, 28 years) and five healthy older volunteers (mean age, 58 years) were recruited for comparison purposes. In patients, the severity of stenoses was also assessed by digital subtraction angiography and intraarterially measured transstenotic pressure drops. We found flow patterns to be statistically significantly (P < 0.01) age-related. Younger healthy subjects showed shorter wave duration, higher diastolic flow, and total blood flow per minute. Also, with increasing stenosis severity, the systolic wave became more damped and the systolic wave duration became statistically significantly (P = .03) longer.