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Chronic lymphocytic leukemia: changes in bone marrow composition and distribution assessed with quantitative MRI
F E Lecouvet1, B C Vande Berg, L Michaux
1Department of Radiology and Medical Imaging, St. Luc University Hospital, University of Louvain, Brussels, Belgium.
Journal of Magnetic Resonance Imaging : JMRI
|June 17, 1998
Summary
Quantitative MRI reveals bone marrow abnormalities in over half of chronic lymphocytic leukemia (CLL) patients, showing good agreement between axial and peripheral marrow assessments. However, MRI missed infiltration in 41% of cases.
Area of Science:
- Radiology
- Oncology
- Hematology
Background:
- Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy.
- Bone marrow involvement is a hallmark of CLL, impacting disease progression and treatment response.
- Accurate assessment of bone marrow infiltration is crucial for staging and management.
Purpose of the Study:
- To determine the prevalence of bone marrow abnormalities in CLL using quantitative MRI.
- To assess agreement and compare sensitivities of axial and peripheral marrow MR assessments.
- To correlate MR findings with clinical and laboratory parameters in CLL patients.
Main Methods:
- Quantitative MRI was used to assess bone marrow composition in 29 CLL patients.
- Measurements included T1 relaxation times of vertebral bone marrow and nonfatty marrow proportion in the proximal femur.
- MR findings were correlated with clinical data and laboratory parameters, including lymphocytosis.
Main Results:
- 41% of patients showed increased lumbar marrow T1 values, and 55% had increased nonfatty marrow in the proximal femur.
- Agreement between axial and peripheral marrow MR assessments was 79%.
- Abnormal marrow findings correlated with higher blood and marrow lymphocytosis.
Conclusions:
- Quantitative MRI demonstrates parallelism between axial marrow composition and peripheral marrow distribution changes in CLL.
- MRI is a valuable tool for assessing bone marrow abnormalities in CLL.
- Limitations exist, as quantitative MRI failed to detect leukemic infiltration in 41% of patients.