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Comparison of Multi-Test device skin testing and modified RAST results
J L Levine1, R L Mabry, C S Mabry
1Department of Otorhinolaryngology, University of Texas Southwestern Medical Center, Dallas 75235-9035, USA.
Summary
A negative Multi-Test skin allergy test reliably indicates no significant allergy. However, positive results require further allergy testing, such as radioallergosorbent (RAST) tests, for confirmation.
Area of Science:
- Allergy and Immunology
- Diagnostic Testing
Background:
- Inhalant allergy diagnosis relies on accurate testing methods.
- Comparing skin tests with blood tests is crucial for validation.
Purpose of the Study:
- To evaluate the correlation between Multi-Test skin tests and radioallergosorbent (RAST) blood tests.
- To assess the diagnostic accuracy of the Multi-Test system for inhalant allergies.
Main Methods:
- Twenty patients with suspected inhalant allergies were tested.
- Both Multi-Test (14 antigens) and RAST testing were performed.
- Wheal size, Multi-Test grade, and RAST class were analyzed.
Main Results:
- Poor correlation was found between positive Multi-Test and RAST results (56.26% average agreement).
- High agreement was observed for negative results (95.15% overall, 83.99% average).
- Negative Multi-Test results strongly predicted the absence of significant allergy.
Conclusions:
- A negative Multi-Test result suggests inhalant allergy is unlikely.
- Positive Multi-Test results warrant further investigation with RAST or additional skin tests.
- The Multi-Test system is a useful screening tool for ruling out inhalant allergies.