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Related Experiment Videos

[Silicone and autoimmune diseases]

J Alijotas Reig1, M I García Domingo

  • 1Departamento de Medicina, Institut Universitari Dexeus, Barcelona.

Anales De Medicina Interna (Madrid, Spain : 1984)
|June 18, 1998
PubMed
Summary
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Silicone implants may be linked to autoimmune diseases like scleroderma. While research is ongoing, physicians should consider this possibility and evaluate patient history for autoimmune disorders.

Area of Science:

  • Immunology
  • Rheumatology
  • Biomaterials Science

Context:

  • Controversy exists regarding the link between silicone implants and autoimmune diseases.
  • Silicone is not inert; microparticles can migrate, potentially causing immune reactions.
  • Silicone has been notably associated with scleroderma and human adjuvant disease.

Purpose:

  • To explore the potential relationship between silicone implants and autoimmune conditions.
  • To highlight the clinical observations and associations reported in the literature.

Summary:

  • Scleroderma has been observed in 50% of patients with autoimmune diseases linked to silicone implants.
  • Prosthesis removal results in favorable outcomes for 50% of symptomatic patients.
  • Pre-implant evaluation of autoimmune history and regular post-implant check-ups are crucial.

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Impact:

  • Emphasizes the need for physician awareness regarding silicone implants and autoimmune disease possibility.
  • Suggests careful patient selection and monitoring for individuals with silicone implants.
  • Informs clinical practice regarding the potential immunogenicity of silicone biomaterials.