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The functional significance of multimerization in ion channels
1Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK. mlt1@mrc-lmb.cam.ac.uk
Current Opinion in Structural Biology
|June 19, 1998
Abstract:
Recently, the allosteric behavior of ion channels has been investigated by recording the individual steps leading to the complete activation of a cyclic nucleotide-gated ion channel. This information, in combination with recent studies on nicotinic acetylcholine receptor mutants, necessitates a modification of our current theories of the allosteric mechanisms of ion channels and gives new insights into the functional significance of multimerization in ion channels.