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Updated: Jul 29, 2026
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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
Published on: May 15, 2013
Perfluorocarbon induced alterations in pulmonary mechanics
D M Eckmann1, M A Swartz, M R Glucksberg
1Department of Anesthesia, University of Pennsylvania, Philadelphia 19104, USA.
Summary
Perfluorocarbon (PFC) compounds caused pulmonary hyperinflation in rabbits due to intra-airway foam formation. This foam traps air, increasing lung volumes and decreasing compliance, impacting respiratory function.
Area of Science:
- Respiratory Physiology
- Toxicology
- Biomedical Engineering
Background:
- Perfluorocarbon (PFC) compounds are used in medical applications.
- Intravenous administration of PFCs can lead to pulmonary complications.
- Pulmonary hyperinflation and respiratory distress are potential adverse effects.
Purpose of the Study:
- To quantify the effects of two PFC emulsions on lung volumes and compliance.
- To identify the mechanism responsible for PFC-induced pulmonary hyperinflation.
- To evaluate the safety of Fluosol and Oxygent in a rabbit model.
Main Methods:
- New Zealand White rabbits were administered saline, Fluosol, or Oxygent intravenously.
- Lung volumes (functional residual capacity, vital capacity, thoracic gas volume) and lung compliance were measured.
- Histological examination of lung tissue was performed to identify pathological changes.
Main Results:
- Fluosol significantly increased functional residual capacity and thoracic gas volume compared to saline and Oxygent.
- Fluosol administration resulted in lower vital capacity and lung compliance.
- Histopathology revealed intra-airway foam formation in PFC-treated animals, consistent with gas trapping.
Conclusions:
- Intra-airway foam formation is the primary mechanism for PFC-induced pulmonary hyperinflation.
- Gas trapping shifts tidal breathing to a less compliant portion of the pressure-volume curve.
- PFC emulsions can have significant adverse effects on respiratory mechanics.
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