Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function

M T Lin1, H J Tsay, W H Su

  • 1Department of Physiology, National Yang-Ming University, Taipei, Taiwan, Republic of China.

The American Journal of Physiology
|June 27, 1998
PubMed
Summary

Altering hypothalamic serotonin (5-HT) levels impacts body temperature regulation in rats. Increased 5-HT activates 5-HT2 receptors causing hyperthermia, while decreased 5-HT via 5-HT1A receptors causes hypothermia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Brain activity alterations in chronic cough: a resting-state functional magnetic resonance imaging study].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Annual advances in clinical studies of chronic cough (2024)].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Advances in clinical studies of chronic cough].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2023
Same author

Specific heat of single-crystal PrMnO<sub>3</sub>.

Journal of physics. Condensed matter : an Institute of Physics journal·2020
Same author

[Gene screening and phenotype analysis in a pedigree with familial hypertrophic cardiomyopathy from Yunnan Province].

Zhonghua xin xue guan bing za zhi·2018
Same author

Human T-lymphotropic Virus Type II Infection inVietnamese Thalassemic Patients.

Archives of virology·2017

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • Serotonin (5-HT) plays a crucial role in regulating physiological functions.
  • The hypothalamus is a key brain region involved in thermoregulation.

Purpose of the Study:

  • To investigate the specific effects of modulating hypothalamic serotonin levels on thermoregulation in rats.
  • To elucidate the roles of different serotonin receptor subtypes in hypothalamic temperature control.

Main Methods:

  • Local hypothalamic perfusion with various agents (5-HT precursor, reuptake inhibitor, high potassium, tetrodotoxin, zero calcium) in unanesthetized rats.
  • Systemic and intrahypothalamic administration of specific serotonin receptor agonists (8-OH-DPAT for 5-HT1A, 2,5-dimethoxy-4-iodophenyl)-2-aminopropane for 5-HT2).
  • Monitoring of colonic temperature (Tco) and extracellular hypothalamic 5-HT concentrations.

Related Experiment Videos

Main Results:

  • Increased hypothalamic 5-HT levels (via 5-hydroxytryptophan, fluoxetine, or high potassium) led to a significant rise in Tco.
  • Decreased hypothalamic 5-HT levels (via tetrodotoxin, zero calcium, or systemic 8-OH-DPAT) resulted in a decrease in Tco.
  • Intrahypothalamic 8-OH-DPAT (5-HT1A agonist) caused hypothermia, while the 5-HT2 agonist caused hyperthermia.

Conclusions:

  • Elevating hypothalamic serotonin activates postsynaptic 5-HT2 receptors, inducing hyperthermia.
  • Stimulating presynaptic 5-HT1A receptors in the hypothalamus reduces serotonin release, leading to hypothermia.
  • These findings highlight the complex, receptor-mediated role of serotonin in hypothalamic thermoregulation.