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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

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Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
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Related Experiment Video

Updated: May 5, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
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Colonic perforation in Crohn's disease

J Fisher, F Mantz, W G Calkins

    Gastroenterology
    |November 1, 1976
    PubMed
    Summary

    Free colon perforation in Crohn's disease is a rare but serious complication. This study details three cases, suggesting it may be more common than previously thought and unrelated to obstruction or steroid use.

    Area of Science:

    • Gastroenterology
    • Colorectal Surgery
    • Pathology

    Background:

    • Crohn's disease is a chronic inflammatory bowel disease.
    • Colonic perforation is a known complication, but free perforation is considered rare.
    • Understanding the characteristics of colonic perforation in Crohn's disease is crucial for patient management.

    Observation:

    • This report details three cases of acute, free perforation of the colon in patients with Crohn's disease.
    • Clinical and pathological features of these cases were analyzed.
    • The occurrence of perforation was assessed in relation to obstruction and adrenocorticosteroid therapy.

    Findings:

    • Colonic perforation in Crohn's disease showed no clear link to obstruction or adrenocorticosteroid therapy.

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  • Perforation can occur with or without toxic megacolon.
  • Pathological examination did not reveal a common pathogenetic mechanism for these perforations.

    • Implications:

    • Free perforation of the colon in Crohn's disease may be underdiagnosed and more frequent than previously reported.
    • Further research is needed to elucidate the pathogenetic mechanisms.
    • Awareness of this complication is important for timely diagnosis and treatment in Crohn's disease patients.