Case selection and treatment considerations of guided tissue regeneration in deep intrabony defects

Evidence reported in the period covered by this review, and here summarized with a meta-analysis, indicated that guided tissue regeneration (GTR) management of deep intrabony defects resulted in clinically significant and predictable gains in tooth support. Controlled randomized clinical trials demonstrated that GTR therapy was associated with significantly greater improvements in clinical attachment than access flap procedures alone. A series of recent investigations have also indicated that the magnitude and possibly the predictability of the expected outcomes are dependent upon a variety of patient, defect, and procedure-associated factors. Substantial evidence has been provided that clinical improvements obtained with GTR can be maintained over time.