Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Combinatorial chemistry using polymer-supported reagents

S W Kaldor1, M G Siegel

  • 1Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company Indianapolis, IN 46285, USA. Kaldor@lilly.com

Current Opinion in Chemical Biology
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improvement in schizophrenics following histamine and steroid therapy as revealed in psychological tests. Part IV. Endocrinologic orientation to psychiatric disorders.

Journal of clinical and experimental psychopathology·2014
Same author

N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.

Journal of medicinal chemistry·2001
Same author

Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent.

Bioorganic & medicinal chemistry letters·2001
Same author

Solution phase synthesis of libraries of variably substituted olefin scaffolds: a library of allylic amines.

Journal of combinatorial chemistry·2001
Same author

Levels of carbon dioxide in helmet systems used during orthopaedic operations.

The Journal of bone and joint surgery. American volume·1998
Same author

Arthroscopic-assisted outpatient anterior cruciate ligament reconstruction using the semitendinosus and gracilis tendons.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·1998
Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026
Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026
Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026
Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026
Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026
Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026
See all related articles

Combinatorial chemistry now uses hybrid methods, including polymer-supported reagents. These tools accelerate the discovery and optimization of potential new drugs.

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis

Background:

  • Combinatorial chemistry has evolved beyond traditional solid- and solution-phase synthesis.
  • Hybrid approaches are increasingly important in modern drug discovery.

Purpose of the Study:

  • To highlight the utility of polymer-supported reagents in combinatorial chemistry.
  • To emphasize their role in accelerating the identification and refinement of pharmaceutical leads.

Main Methods:

  • Review of hybrid combinatorial chemistry techniques.
  • Focus on the application of polymer-supported reagents.

Main Results:

  • Polymer-supported reagents offer significant advantages in combinatorial synthesis.
  • These methods streamline the process of lead compound discovery.

Related Experiment Videos

Conclusions:

  • Polymer-supported reagents are valuable tools in modern pharmaceutical research.
  • Their application enhances the efficiency of drug discovery and optimization.