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Related Experiment Videos

Antimicrobial agents

K Bush1

  • 1RW Johnson Pharmaceutical Research Institute, Route 202-Box 300, Raritan, NJ 08869-0602, USA. kbush@prius.jnj.com

Current Opinion in Chemical Biology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Developing new antimicrobial agents against multi-resistant Gram-positive bacteria is crucial. Promising drug classes include streptogramins, glycopeptides, oxazolidinones, and quinolones, with novel targets under investigation.

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Area of Science:

  • Microbiology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • Multi-resistant Gram-positive bacteria pose a significant public health threat.
  • There is a high commercial demand for effective antimicrobial agents targeting these resistant strains.

Purpose of the Study:

  • To review current and emerging antimicrobial agents effective against multi-resistant Gram-positive bacteria.
  • To identify novel compound classes with potential therapeutic utility.

Main Methods:

  • Literature review of recent clinical trials and drug development pipelines.
  • Analysis of chemical structures and mechanisms of action for various antimicrobial classes.

Main Results:

  • Streptogramins, novel glycopeptides, oxazolidinones, and potent quinolones have shown commercial viability.

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  • Cationic peptides show limited utility as drug candidates.
  • Emerging targets include non-beta-lactam beta-lactamase inhibitors, lipid A biosynthesis inhibitors, and tRNA synthetase inhibitors.

    • Conclusions:

    • Several classes of antimicrobial agents are progressing towards clinical application.
    • Further research into novel compound classes is warranted to address the challenge of antimicrobial resistance.