Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug discovery: past, present and future

P N Kaul1

  • 1Clark Atlanta University, GA 30314, USA.

Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progres Des Recherches Pharmaceutiques
|July 22, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Water soluble fractions of rose-scented geranium (Pelargonium species) essential oil.

Bioresource technology·2002
Same author

Alternative medicine: herbal drugs and their critical appraisal--part II.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2001
Same author

Alternative medicine: herbal drugs and their critical appraisal--Part I.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2001
Same author

The essential oil composition of Angelica glauca roots.

Planta medica·1996
Same author

Alternative therapeutic modalities. Alternative medicine.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·1996
Same author

Composition of the Essential Oil of the Leaves of Vitex negundo.

Planta medica·1994

Drug discovery evolved from trial-and-error to rational approaches using molecular biology and computer technology. Future advancements may enable voluntary regulation of physiological processes through bio-feedback.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Biotechnology

Background:

  • Early drug discovery relied on natural substances and serendipity until the mid-20th century.
  • Systematic pharmacological evaluations began in the early 20th century.
  • Serendipitous discoveries dominated new drug development until the 1970s.

Purpose of the Study:

  • To outline the historical evolution of drug discovery methodologies.
  • To highlight the impact of molecular biology and computer technology on rational drug design.
  • To explore future possibilities in drug discovery and physiological regulation.

Main Methods:

  • Review of historical approaches in drug discovery.
  • Integration of molecular biology techniques like gene cloning.

Related Experiment Videos

  • Application of computational advancements in drug design.

    • Main Results:

    • Shift from serendipitous findings to rational, target-based drug discovery from 1980 onwards.
    • Development of receptor-directed and enzyme-directed drug discovery methods.
    • Production of therapeutic biomolecules using recombinant DNA and transgenic technologies.

    Conclusions:

    • Modern drug discovery is based on a rational, scientific foundation.
    • Advances enable the development of targeted therapies and endogenous biomolecules.
    • Future potential lies in bio-feedback for voluntary physiological regulation.