Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyamines and cerebral ischemia

T D Johnson1

  • 1Department of Anesthesiology, Baylor College of Medicine, Houston, TX, USA.

Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progres Des Recherches Pharmaceutiques
|July 22, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Fission Yield Data in the Calculation of Antineutrino Spectra for ^{235}U(n,fission) at Thermal and Fast Neutron Energies.

Physical review letters·2016
Same author

Fabrication and characterization of injectable hydrogels derived from decellularized skeletal and cardiac muscle.

Methods (San Diego, Calif.)·2015
Same author

Chronic bilateral basal pulmonary fibrosis; clinical study.

Proceedings [of the] annual meeting. Central Society for Clinical Research (U.S.)·2010
Same author

Utility of the k-means clustering algorithm in differentiating apparent diffusion coefficient values of benign and malignant neck pathologies.

AJNR. American journal of neuroradiology·2009
Same author

Respiratory assessment in child and adolescent residential treatment settings: reducing restraint-associated risks.

Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·2007
Same author

Seven years of treatment with risedronate in women with postmenopausal osteoporosis.

Calcified tissue international·2004
Same journal

Molecular Docking of Bioactive Compounds Against BRCA and COX Proteins.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2016
Same journal

Isolation of Compounds.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2016
Same journal

Detection of Phenolic and Flavonoid Compounds Using High Performance Thin Layer Chromatography (HPTLC).

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2016
Same journal

Protein Bioavailability in Animal Model.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2016
Same journal

Anti-tumour Activity.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2016
Same journal

Induction of Apoptosis.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques·2016
See all related articles

Polyamines, involved in brain injury, may cause neuronal damage after cerebral ischemia by altering ion homeostasis. Understanding polyamine metabolism is key to explaining ischemia-induced neuronal injury.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathophysiology

Background:

  • Alterations in polyamine metabolism are linked to global ischemia in animal models.
  • Recent studies extend this association to focal ischemia and traumatic brain injury.
  • Polyamines are increasingly recognized for their detrimental roles following ischemia-reperfusion injury.

Purpose of the Study:

  • To substantiate the link between ischemia-induced polyamine metabolism alterations and neuronal injury.
  • To explore the physiological relevance of polyamines in the central nervous system (CNS) following ischemic events.
  • To investigate the potential impact of polyamine alterations on ion homeostasis and neuronal damage.

Main Methods:

  • Review of existing literature on polyamine metabolism in CNS ischemia.

Related Experiment Videos

  • Analysis of evidence linking polyamines to neuronal injury mechanisms.
  • Exploration of polyamine interactions with ion channels and receptors.

    • Main Results:

    • Polyamines are implicated in multifaceted detrimental roles post-ischemia-reperfusion.
    • Polyamines modulate key CNS targets, including inward rectifier potassium channels and NMDA/AMPA receptors.
    • Alterations in polyamine levels can significantly affect CNS ion homeostasis, particularly potassium levels.

    Conclusions:

    • The physiological relevance of polyamines in CNS function is becoming clearer.
    • Ischemia-induced alterations in polyamine metabolism likely contribute to neuronal injury by disrupting ion balance.
    • Further research is needed to fully elucidate the complex role of polyamines in cerebral ischemia and develop targeted therapies.