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Related Experiment Videos

Low anion gap

R L Jurado1, C del Rio, G Nassar

  • 1Medical Service, Veterans Affairs Medical Center, Emory University School of Medicine, Atlanta, GA 30033, USA.

Southern Medical Journal
|July 22, 1998
PubMed
Summary
This summary is machine-generated.

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A low anion gap, defined as less than 3 mEq/L, can be a crucial diagnostic clue. Recognizing its significance aids in identifying serious conditions like intoxications or neoplasms.

Area of Science:

  • Clinical Chemistry
  • Internal Medicine
  • Diagnostic Medicine

Background:

  • The anion gap is a calculated measure of the difference between measured cations and anions in serum.
  • Changes in laboratory methodology have altered the normal reference range for the anion gap.

Purpose of the Study:

  • To establish a current definition for a low anion gap.
  • To outline the differential diagnosis for a low anion gap.

Main Methods:

  • Review of English-language literature on the causes of a low anion gap.
  • Analysis of current clinical data to define a low anion gap threshold.

Main Results:

  • A low anion gap is defined as < 3 mEq/L.
  • A low anion gap can indicate life-threatening intoxications or occult neoplasms.

Related Experiment Videos

  • A low anion gap may obscure the detection of high anion gap metabolic acidosis.

    • Conclusions:

    • Interpreting a low anion gap provides significant clinical information.
    • A low anion gap is an important diagnostic tool that is often underutilized.