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Related Experiment Videos

Maturational changes in left ventricular contractile state

M Toyono1, K Harada, Y Takahashi

  • 1Department of Pediatrics, Akita University School of Medicine, Hondo, Japan.

International Journal of Cardiology
|July 22, 1998
PubMed
Summary

Left ventricular contractility in premature infants is similar to full-term infants, showing preserved performance with lower afterload. This study tracked cardiac function from preterm birth through childhood.

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Area of Science:

  • Pediatric Cardiology
  • Neonatal Physiology
  • Echocardiography

Background:

  • Age-related changes in left ventricular contractility are known in adults, but data on infants and children are limited.
  • Understanding growth-related changes in left ventricular performance is crucial for assessing pediatric cardiac health.

Purpose of the Study:

  • To evaluate left ventricular contractility changes from preterm infants to older children.
  • To compare the contractility and afterload sensitivity between premature infants, full-term infants, and children.

Main Methods:

  • Utilized two-dimensional and M-mode echocardiography to assess left ventricular contractility.
  • Employed the rate-corrected mean velocity of fiber shortening (mVcfc) to end-systolic wall stress (ESS) relation as a contractility index.

Related Experiment Videos

  • Analyzed data from 22 preterm infants, 23 full-term infants, and 35 children.

    • Main Results:

    • Significant inverse linear correlations between ESS and mVcfc were observed in all groups (P<0.01).
    • Premature infants and neonates exhibited significantly greater slopes and y-intercepts in the mVcfc-ESS relation compared to children.
    • No significant differences in contractility were found between premature and full-term infants.
    • Serial studies in premature infants showed increased ESS with growth, while mVcfc remained stable, indicating preserved left ventricular performance due to lower afterload.

    Conclusions:

    • Left ventricular contractility and afterload sensitivity in premature infants appear comparable to full-term infants.
    • Left ventricular performance in premature infants is maintained during early life despite increasing afterload, suggesting adaptive mechanisms.
    • This research provides valuable insights into the developmental trajectory of cardiac function in early life.