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[Pressure-reducing effect of latanoprost 0.005%]

C Albach1, E D Wachsmuth, K Velte

  • 1Universitätsaugenklinik, Frauenklinikstrasse 24 Nord II, Zürich.

Klinische Monatsblatter Fur Augenheilkunde
|July 25, 1998
PubMed
Summary

Latanoprost 0.005% improves aqueous humor outflow in the human eye, leading to greater intraocular pressure (IOP) reduction. This study validates a new photometric dye-dilution test for measuring outflow.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Physiology

Background:

  • Previous studies in non-human primates indicated latanoprost 0.005% lowers intraocular pressure (IOP) by enhancing uveoscleral outflow.
  • The mechanism of latanoprost's effect on uveoscleral outflow in the human eye required further investigation.

Purpose of the Study:

  • To determine if latanoprost 0.005% improves aqueous humor outflow in healthy human volunteers.
  • To validate a novel photometric dye-dilution test for assessing aqueous humor dynamics.

Main Methods:

  • A cohort of 9 healthy human volunteers underwent IOP measurement.
  • A single drop of latanoprost 0.005% was administered to one randomly selected eye.
  • Aqueous humor outflow was quantified using a novel dye-dilution test with 2-nitrophenyl-acetate and an ocular photometer.

Main Results:

  • Latanoprost 0.005% significantly shortened the half-life of the dye in the anterior chamber.
  • The observed reduction in dye half-life demonstrated a significant correlation with the IOP-lowering effect of latanoprost.
  • The photometric quantification of 2-nitrophenyl-acetate proved to be a reliable indicator of aqueous humor outflow.

Conclusions:

  • The dye-dilution technique confirms that latanoprost 0.005% positively influences aqueous humor outflow in the human eye.
  • Enhanced aqueous humor outflow correlates directly with a greater reduction in intraocular pressure.
  • Photometric quantification of 2-nitrophenyl-acetate is established as a simple and reliable method for assessing aqueous humor outflow.

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