Related Experiment Videos
Autologous pericardium for ventricular septal defect closure
P H Schoof1, M G Hazekamp, K van Ulzen
1Department of Cardiothoracic Surgery, University Hospital, Leiden, The Netherlands.
The Journal of Heart Valve Disease
|August 11, 1998
Summary
Untreated autologous pericardium patches are safe for pediatric ventricular septal defect (VSD) closure. Proper sizing is crucial to prevent complications like aneurysms, ensuring successful VSD repair.
Area of Science:
- Pediatric Cardiac Surgery
- Cardiovascular Research
- Biomaterials in Medicine
Background:
- Living, untreated autologous pericardium offers a promising option for left ventricular outflow tract patch repair in pediatric patients.
- Autologous pericardium presents an attractive alternative for reconstructive procedures in pediatric cardiology.
Purpose of the Study:
- To evaluate the safety and efficacy of untreated autologous pericardium patches for ventricular septal defect (VSD) closure in children.
- To assess the short-term outcomes and histological response of autologous pericardial patches used in pediatric VSD repair.
Main Methods:
- 102 children underwent VSD closure using untreated autologous pericardial patches.
- Postoperative echocardiography assessed VSD status; one explanted patch underwent microscopic examination.
Main Results:
- Excellent short-term results with 97% of patients showing no or minor residual VSD.
- One patient required reoperation for residual VSD and an aneurysmal patch; oversizing was identified as the cause.
- Microscopic analysis revealed tissue remodeling and thickening, not inflammatory or degenerative changes, indicating successful adaptation.
Conclusions:
- Untreated autologous pericardial patches are a safe and effective alternative for VSD closure in pediatric patients.
- Meticulous intraoperative patch sizing is essential to prevent complications such as aneurysms and ensure optimal outcomes.