Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Percutaneous penetration enhancement and its quantification

M Bach1, B C Lippold

  • 1Institut für Pharmazeutische Technologie, Heinrich-Heine-Universität Düsseldorf, Germany.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 12, 1998
PubMed
Summary

Penetration enhancers increase drug diffusion and solubility in the skin barrier. These effects can be quantified by measuring drug fluxes or pharmacodynamic responses, considering thermodynamic drug activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ISCEV standard for clinical visual evoked potentials (2025 update).

Documenta ophthalmologica. Advances in ophthalmology·2025
Same author

Morphometric analysis of the abducens nerve in the petroclival region.

Frontiers in surgery·2025
Same author

New-generation 0.55T MRI in patients with total hip arthroplasty: a comparison with 1.5T MRI.

Clinical radiology·2024
Same author

Fracture risk prediction in postmenopausal women from GO Study: the comparison between FRAX, Garvan, and POL-RISK algorithms.

Archives of osteoporosis·2024
Same author

ISCEV standard for clinical pattern electroretinography (2024 update).

Documenta ophthalmologica. Advances in ophthalmology·2024
Same author

Optimal fracture prediction thresholds for therapy onset, established from FRAX and Garvan algorithms: a longitudinal observation of the population representative female cohort from the RAC-OST-POL Study.

Archives of osteoporosis·2023

Area of Science:

  • Pharmacology
  • Dermatology
  • Physical Chemistry

Background:

  • Drug penetration through the stratum corneum is crucial for topical and transdermal therapies.
  • Structural alterations of the stratum corneum can enhance drug permeation.
  • Quantifying these enhancing effects is essential for developing effective drug delivery systems.

Purpose of the Study:

  • To elucidate the mechanisms of penetration enhancement.
  • To establish methods for quantifying drug penetration enhancement.
  • To relate penetration enhancement to thermodynamic drug activity.

Main Methods:

  • Direct determination of drug fluxes across the stratum corneum.
  • Indirect determination via pharmacodynamic response measurements.

Related Experiment Videos

  • Consideration of thermodynamic drug activity in all measurements.

    • Main Results:

    • Penetration enhancers increase the drug diffusion coefficient (DB) and/or drug solubility in the barrier (csB).
    • Pharmacodynamic measurements allow quantification of enhancement by comparing activity-response lines.
    • Activity-standardized bioavailability factors (fa) reflect enhancer-induced changes in permeability (PB).

    Conclusions:

    • Penetration enhancement can be accurately quantified using direct or indirect methods.
    • Thermodynamic drug activity is a critical factor in assessing enhancement effects.
    • Understanding these principles aids in the design of improved transdermal drug delivery systems.