Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Introduction to a new inspiratory threshold loading device

R C Chen1, C L Que, S Yan

  • 1Meakins-Christie Laboratories, McGill University, Montreal, Québec, Canada.

The European Respiratory Journal
|August 13, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Annual advances in clinical research on mechanical ventilation in management of respiratory failure 2025].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026
Same author

[Annual progress in chronic obstructive pulmonary disease 2025].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2026
Same author

[A multicenter, prospective, observational study of cough variant asthma in China: clinical features, airway inflammation, and prognosis].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Progress on biologic therapies for severe asthma].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Clinical research progress in non-invasive positive pressure ventilation from 2023 to 2024].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Annual research progress in chronic obstructive pulmonary disease 2024].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same journal

Beyond the 5th percentile: rethinking diagnostic thresholds in pulmonary function testing.

The European respiratory journal·2026
Same journal

A Transcriptomic Atlas of Chronic Lung Allograft Dysfunction.

The European respiratory journal·2026
Same journal

Risk of cancer and mortality in patients with interstitial lung diseases: Danish cohort study.

The European respiratory journal·2026
Same journal

Proposing a minimal important difference in NTproBNP in pulmonary arterial hypertension.

The European respiratory journal·2026
Same journal

Unlocking growth potential: Ivacaftor therapy and developmental gains in lung and height in a cohort study of children and young adults with cystic fibrosis.

The European respiratory journal·2026
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
See all related articles

A new inspiratory threshold loading system precisely measures inspiratory muscle function. This device offers a constant load with minimal resistance, ideal for respiratory mechanics research.

Area of Science:

  • Respiratory Physiology
  • Biomedical Engineering

Background:

  • Inspiratory threshold loading is crucial for assessing inspiratory muscle function and respiratory mechanics.
  • Existing methods may lack precision or purity in delivering threshold loads.

Purpose of the Study:

  • To design and validate a simple, precise system for generating pure inspiratory threshold loads.
  • To evaluate the system's performance in providing consistent loads with minimal resistance.

Main Methods:

  • A novel inspiratory threshold loading system was developed using a flow generator and pressure chamber connected to a Hans-Rudolph valve.
  • The system was tested in four subjects, measuring mouth pressure (Pm), threshold pressure (Pth), and valve resistance (R).
  • Opening pressure (Pop) was defined as Pm at the start of inspiratory flow.

Related Experiment Videos

Main Results:

  • The system generated a constant threshold pressure (Pth) throughout inspiration.
  • Opening pressure (Pop) showed a linear relationship with Pth (p<0.0001), with high accuracy.
  • Valve resistance (R) was consistently low (0.7-1.1 cmH2O·L⁻¹·s⁻¹) and independent of Pth and inspiratory flow.

Conclusions:

  • The developed system reliably provides a pure and constant inspiratory threshold load.
  • Its low and consistent flow resistance makes it an ideal tool for respiratory studies.
  • This system enhances the assessment of inspiratory muscle function and respiratory mechanics.