Related Experiment Videos
Experimental evaluation of hepatic functional reserve using 111In colloid for clinical application
T Sugiu1, K Hamazaki, S Sakumoto
1First Department of Surgery, Okayama University Medical School, Japan.
In Vivo (Athens, Greece)
|August 26, 1998
Summary
Researchers developed 111In colloid as a safe alternative to 198Au colloid for assessing hepatic blood flow (KL). This new method accurately reflects liver function and hepatic tissue blood flow in various liver conditions.
Area of Science:
- Hepatology
- Radiopharmacology
- Surgical Research
Background:
- Reduced hepatic blood flow is linked to postoperative hepatic insufficiency.
- 198Au colloid was previously used to estimate hepatic blood flow index (KL) but is now unavailable due to radioactivity.
- 111In colloid is proposed as a safer substitute for evaluating hepatic functional reserve.
Purpose of the Study:
- To investigate the clinical applicability of 111In colloid for assessing hepatic blood flow.
- To validate 111In colloid's hepatic blood flow index (KL) against established methods and in different liver conditions.
Main Methods:
- Induced liver cirrhosis in rats using CCl4.
- Measured hepatic blood flow index (KL) using 111In colloid and hepatic tissue blood flow (HL) using hydrogen gas clearance.
- Modulated reticuloendothelial function with Zymosan A and Silica.
- Assessed KL and HL in 30% and 70% hepatectomy models.
Main Results:
- A significant correlation was found between KL estimated by 111In colloid and HL (r = 0.83, p < 0.01) in normal and cirrhotic livers.
- KL values remained stable despite modulation of reticuloendothelial function.
- KL and HL exhibited similar changes after 30% and 70% hepatectomy.
Conclusions:
- The clearance of 111In colloid serves as a reliable clinical index for hepatic blood flow.
- 111In colloid is a viable and safe alternative for assessing hepatic functional reserve.
- This method holds promise for monitoring liver health in clinical settings.