Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Topiramate--safety and tolerability

M W Jones1

  • 1Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Summertime methane and carbon dioxide emission rates and associated variables from a national-scale survey of 146 reservoirs in the United States.

Limnology and oceanography letters·2026
Same author

Integrated fire management as an adaptation and mitigation strategy to altered fire regimes.

Communications earth & environment·2025
Same author

Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS).

Psychological medicine·2019
Same author

The Mdm1 Locus and Maize Resistance to Maize dwarf mosaic virus.

Plant disease·2019
Same author

Palacos and peanut allergy.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2017
Same author

Step by step: reconstruction of terrestrial animal movement paths by dead-reckoning.

Movement ecology·2015
Same journal

Practice Patterns and Care Gaps in Lennox Gastaut Syndrome: A call for Action.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Isolated Achiasma Discovered at Age 86: A Rare Cause of see-saw nystagmus and bitemporal hemianopia.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Post-Stroke Parakinesia Brachialis Oscitans: Clinical Insights from a Case Series.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

A Neuronal Perspective.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Diagnostic efficacy, costs, and safety of portable ultra-low field MRI in brain imaging: a systematic review.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Chronology of Non-Motor Symptoms in 100 Patients with Advanced PD of 10 Years' Duration: Pre- versus Post-Motor Period.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
See all related articles

Topiramate, an adjunctive treatment for intractable seizures, shows a favorable safety profile with no serious systemic side effects. However, cognitive side effects and weight loss may occur, with higher doses being less tolerated.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Intractable seizures require novel therapeutic options.
  • Topiramate is a new adjunctive antiepileptic drug.

Purpose of the Study:

  • To review safety and tolerability data of topiramate from controlled studies.
  • To evaluate the efficacy and side effect profile of topiramate in seizure management.

Main Methods:

  • Review of seven double-blind, placebo-controlled studies.
  • Analysis of safety and tolerability data across varying topiramate doses.

Main Results:

  • No serious systemic side effects (rash, hepatotoxicity, cardiotoxicity, etc.) were observed.
  • Renal stones occurred in 1.5% of patients; 80% continued treatment due to improved quality of life.

Related Experiment Videos

  • "Abnormal thinking" (slowed cognition, calculation difficulties) linked to rapid titration and high doses.
  • Weight loss (10-20%) associated with appetite suppression.
  • Seizure reduction increased with dose, but doses >600 mg/day were poorly tolerated.

    • Conclusions:

    • Topiramate is a generally safe and tolerable adjunctive treatment for intractable seizures.
    • Cognitive side effects and weight loss are potential adverse events.
    • Optimal dosing is crucial to balance efficacy and tolerability, avoiding doses over 600 mg/day.