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Synthesis and antiviral evaluation of pyrazinones substituted with acyclic chains
J Davis1, R Benhaddou, R Granet
1Laboratoire de Chimie des Substances Naturelles, Université de Limoges, France.
Nucleosides & Nucleotides
|August 26, 1998
Abstract:
The synthesis of a series of pyrazine analogues of the anti-herpes compound, acyclovir is described. These syntheses were accomplished by various methods: in the presence of a Lewis acid or NaH for hydroxyethoxymethyl and hydroxybutyl groups or by sequential oxidation/reduction of 1-(beta-D-ribofuranosyl)-2-pyrazinones for 2',3'-acyclonucleosides. Antiviral (HSV-1, CMV, Cox B4, HIV-1) properties of these compounds were determined.