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Related Experiment Videos

Autonomic dysfunction in vitamin B12 deficiency: a heart rate variability study

A B Sözen1, S Demirel, V Akkaya

  • 1University of Istanbul, Istanbul Faculty of Medicine, Cardiovascular Research Center, Turkey.

Journal of the Autonomic Nervous System
|August 29, 1998
PubMed
Summary

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Vitamin B12 deficiency, linked to pernicious anemia, may cause autonomic dysfunction. Heart rate variability analysis revealed significant differences in key parameters between deficient patients and controls.

Area of Science:

  • Cardiology
  • Neurology
  • Endocrinology

Background:

  • Autonomic dysfunction is a complex condition affecting involuntary bodily functions.
  • Vitamin B12 deficiency, particularly in pernicious anemia, has been anecdotally linked to neurological symptoms.
  • Understanding the specific impact of B12 deficiency on the autonomic nervous system is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the potential causal relationship between vitamin B12 deficiency and autonomic dysfunction.
  • To assess heart rate variability (HRV) parameters in patients with pernicious anemia compared to healthy controls.

Main Methods:

  • A case-control study involving 12 patients with pernicious anemia and 12 age- and sex-matched controls.
  • Analysis of time-domain and frequency-domain heart rate variability parameters using Holter monitoring.

Related Experiment Videos

  • Statistical comparison of HRV metrics including SDNN, SDANN, SD, rMSSD, pNN50, total power, low frequency power, and high frequency power.

    • Main Results:

    • Patients with vitamin B12 deficiency exhibited significantly lower time-domain HRV parameters: SDNN, SDANN, SD, and rMSSD.
    • Frequency-domain analysis showed significantly reduced total power, low frequency power, and high frequency power in the B12 deficient group.
    • No statistically significant difference was observed in the pNN50 parameter between the groups.

    Conclusions:

    • Vitamin B12 deficiency is associated with significant autonomic dysfunction.
    • HRV analysis provides objective evidence supporting the link between B12 deficiency and impaired autonomic function.
    • These findings underscore the importance of assessing autonomic function in patients with vitamin B12 deficiency.