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Related Experiment Videos

Clocked gene expression in somite formation

C D Stern1, D Vasiliauskas

  • 1Department of Genetics and Development, Columbia University, New York, NY 10032, USA. cds20@columbia.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|September 2, 1998
PubMed
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Gene expression in chick embryos shows a 90-minute cycle during somite formation. This discovery highlights the role of timing in creating spatial patterns for embryonic development.

Area of Science:

  • Developmental biology
  • Molecular biology
  • Genetics

Background:

  • Somite formation is a key process in vertebrate embryonic development.
  • The segmentation clock, a molecular oscillator, controls somite formation.
  • Hairy-related genes are involved in segmentation clock mechanisms.

Purpose of the Study:

  • To investigate the expression pattern of c-hairy1, a chick ortholog of the fly hairy gene, during somite formation.
  • To determine the periodicity and spatial patterns of c-hairy1 mRNA expression.
  • To elucidate the role of temporal gene regulation in establishing spatial patterns during somitogenesis.

Main Methods:

  • Analysis of c-hairy1 mRNA expression patterns in chick embryos using in situ hybridization.
  • Experimental manipulations to assess the temporal dynamics of c-hairy1 expression.

Related Experiment Videos

  • Quantitative analysis of gene expression oscillations and periodicity.

    • Main Results:

    • c-hairy1 mRNA exhibits dynamic spatial patterns in the presomitic mesoderm prior to segmentation.
    • These spatial patterns correspond to distinct temporal phases of gene expression.
    • A precise 90-minute periodicity was identified for c-hairy1 expression, indicating a functional segmentation clock.

    Conclusions:

    • The study reveals a precise temporal oscillation of c-hairy1 expression during chick somitogenesis.
    • This finding provides strong evidence for a molecular clock regulating embryonic segmentation.
    • Temporally regulated gene expression is crucial for the precise spatial patterning of somites.